Person in charge
Jean-Marie Dupret
Pharmacogenomics of Enzymes for Xenobiotic Metabolism
Objectives
To address the biological basis of pharmacogenomics. The main mechanisms of biotransformation of xenobiotics and the impact of these processes on the risk of adverse drug reactions and the occurrence of cancers are also presented.
Lectures 14h
Basics of pharmacogenomics, genetic polymorphisms
Enzymes and metabolism of xenobiotics
Xenobiotic receptors
Adverse drug reactions
Metabolism of carcinogens and cancers
Tutorial works 28h
Analysis of scientific articles
Targeted skills
- To contribute to the design and implementation of fundamental or applied research projects in pharmacogenomics
- To obtain and analyze scientific data with numerical reference tools
- Understanding a rigorous scientific and experimental approach
- Ability to communicate scientific information and results in writing and orally.
- Mastery of scientific English
- Ability to speak and debate
Arylamine N-acetyltransferase,
a major enzyme in the metabolism of xenobiotics,
with pharmacogenomic properties