Persons in charge
Claudine Mayer – Jean-Marie Dupret
Macromolecular architecture and biological reactions
Objectives
To understand the three-dimensional aspects of biology, become familiar with the basics of structural biology techniques.
To understand the kinetic bases of enzymatic catalysis and biochemical reactions.
To understand enzymatic reactions with two substrates.
To understand enzyme regulation and its metabolic and pathological implications.
Lectures 28h
Introduction biochemistry of macromolecules
Macromolecule structures (DNA, proteins) Revisions
Metabolic regulations and enzymopathies
Biophysical methods
Structural biology techniques
Rapid pre-stationary reactions
Enzymatic reactions and thermodynamics
Single molecule approaches
Two-substrate reactions
Tutorials works 20h
Biophysics of macromolecules
Structural Biology I
Structural Biology II
Enzymes with two substrates
DNA/protein structure and interaction
Structural Bioinformatics
Rapid reactions and thermodynamics
Allosteric regulation and metabolism
Targeted skills
- Contributing to the design and implementation of fundamental or applied research projects in structural biology and/or enzymology
- Obtain and analyze scientific data with numerical reference tools
- Understanding a rigorous scientific and experimental approach
- Ability to communicate scientific information and results in writing and orally.
- Mastery of scientific English
- Ability to speak and debate